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pentobarbital decreases levels of toremifene by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. CYP3A4 inducers increase level of toremifene metabolism, decreasing the regular-state concentration in serum.lasmiditan, pentobarbital. Both raises effects of the other by sedation. Use Warning/Keep track of. Coadministration